Biomaterials for replacement or repair of damaged tissues are utilized in a number of surgical procedures. The ideal material needs to be strong, easy to handle, and biocompatible, while supporting growth of new tissue.
The ideal biomaterial would allow tissue incorporation and result in remodeled, functional tissue without leading to encapsulation, premature breakdown of the material, tissue erosion or adhesion formation.
The SIS Tissue Repair Products:
Unlike some other biologic grafts, SIS tissue repair products communicate with the body-signaling surrounding tissue to grow across and incorporate into the extracellular matrix. This allows the body to restore itself. SIS products provide an environment that promotes rapid tissue remodeling. The result is completely remodeled, strong, fully vascularized host tissue.
For a biomaterial to be able to repair a complex and often contaminated defect, it must be able to signal the influx of host defenses to fend off infection. Because SIS products facilitate angiogenesis and rapidly remodel into vascularized host tissue, they allow the body's own defense mechanisms to reach and respond to infection.
Ideally, a biomaterial should produce a permanent repair without permanent material. SIS tissue repair products facilitate complete remodeling. This new, site-specific remodeled tissue displays similar physiologic and morphologic characteristics as native tissue. Once the healing process is complete, SIS tissue repair products are replaced by the body's own tissue–leaving behind a permanent repair without the long-term presence of a foreign body.
Over time, SIS tissue repair products remodel to maintain strength while becoming the patient's own tissue.
